Mycobacterium tuberculosisthymidylate kinase: structural studies of the enzymatic reaction
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چکیده
منابع مشابه
analysis of reading comprehension needs of the students of paramedical studies: the case of the students of health information management (him)
چکیده ندارد.
15 صفحه اول[Quantum chemical studies on enzymatic reaction mechanisms].
Computer modeling of enzymes is a valuable complement to experiments. Quantum chemical studies of enzymatic reactions can provide a detailed description of the reaction mechanism and elucidate the roles of various residues in the active site. Different reaction pathways can be analyzed, and their feasibility be established based on calculated energy barriers. In the present thesis, density func...
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A highly purified preparation of arginine kinase from the tail muscle of the crayfish, Panulirus longipes, has been used to investigate the mechanism of the reaction. The results of initial velocity, product inhibition, and isotope exchange at equilibrium studies are consistent with the reaction having a random mechanism in which all the steps are in rapid equilibrium except those concerned wit...
متن کاملEnzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism.
The chemical synthesis of new compounds designed as inhibitors of Mycobacterium tuberculosis TMP kinase (TMPK) is reported. The synthesis concerns TMP analogues modified at the 5-position of the thymine ring as well as a novel compound with a six-membered sugar ring. The binding properties of the analogues are compared with the known inhibitor azido-TMP, which is postulated here to work by excl...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations of Crystallography
سال: 2002
ISSN: 0108-7673
DOI: 10.1107/s0108767302088992